Tony Means, PhD, and his team at the Duke University Medical Center were able to tone down appetite and promote weight loss, while improving the body’s ability to handle blood sugar levels, when they blocked a brain enzyme, CaMKK2, in mice.
“We believe we have identified an important drug development target that could potentially turn into a metabolic triple play: appetite control, weight loss and blood sugar management,” said Means, who is the Nanaline H. Duke Professor and Chairman of Pharmacology and Cancer Biology.
For many years, scientists have been identifying and testing every step of the appetite stimulation and suppression pathways in search of a target. Such research is considered critical to finding ways for people to better control their weight and minimize their risk of developing diabetes, heart disease and other health conditions. Activation of the enzyme CaMKK2 is just one step in the appetite stimulation pathway located in the hypothalamus section of the brain. An empty stomach releases the hormone ghrelin, which launches a cascade of signals that ultimately results in increased appetite.
Means and colleagues believed that CaMKK2 in the ghrelin pathway might be a likely candidate for study, because it activates AMPK, an enzyme that stimulates animals to eat and gain weight. They tested their theory in several ways, the results of which are published in the May issue of Cell Metabolism. The work was funded by NIH grants, as well as by the Australian Research Council, National Heart Foundation and the National Health and Medical Research Council of Australia.
First they blocked CaMKK2 in mice with a specialized molecule inhibitor and then measured food intake. These mice ate significantly less food than untreated mice during the six days in which they were evaluated, and also lost body weight, which led the scientists to think they might be on to something. Next they studied a group of mice that normally do not make CaMKK2 and found that the molecule inhibitor did not change feeding behavior or reduce weight. “The fact that blocking CaMKK2 worked in normal mice to make them eat less and lose weight, but not in mice missing the enzyme, provides compelling evidence that CaMKK2 signaling is a requirement for appetite control,” Means said.
Release date: May 6, 2008Duke University Medical Center
- Adele’s ex-PT reveals 3 top tips for weight loss
- Scarlett Moffatt's rise and spectacular fall - from Gogglebox queen to weight loss scandal
- Bharti Airtel share price down 3% on reports of promoter stake sale, volume surge
- Losing Weight Helps Immune System
- My husband died of brain cancer without knowing I was pregnant – then I miscarried
- Testosterone jabs saved me from the 'manopause', says Olympic star Cracknell as he reveals he is finally conquering the cruel after-effects of the brain damage from his devastating bike crash
- Discovery of new ‘thin gene’ could pave the way for new obesity treatments
- Arshad Warsi loses 6 kilos in a month with Keto and Intermittent Fasting
- Gemma Collins looks radiant as she displays her slimmed-down frame in an orange lace summer dress after declaring she's 'never felt so good'
- 'Thinness Gene' Could Explain Some People Stay Slim Without Trying
- The 'unexpected' foods sabotaging your healthy eating goals: Nutritionist reveals how staples like sliced bread and soup contain hidden sugar, salt and fat that fuel cravings - and shares her tips on how to resist
- Check out all the benefits that come from drinking jeera water
- Cell receptors found in the nose, lungs and gut could be the reason why being overweight (or a man) makes YOU more at risk of catching coronavirus
- The 8 ways to reverse type 2 diabetes – as it’s linked to almost a THIRD of Covid deaths
- Is it safe to take painkillers every day... and how can I tell if I have a fever without a thermometer? DR ELLIE CANNON answers 50 questions we all want to ask a GP
- 10 Soothing Drinks For The Summer Season To Beat The Heat
- World Hypertension Day: Monitor BP, workout daily & eat healthy to boost immunity and keep corona at bay
- 'I never thought I would be a teacher': Gemma Collins reveals she is homeschooling her nephew amid the coronavirus lockdown
Blocked Brain Enzyme Decreases Appetite and Promotes Weight Loss have 678 words, post on www.dddmag.com at May 6, 2008. This is cached page on Auto News. If you want remove this page, please contact us.